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Article

Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice.

Behavioural brain research - 1 Feb 2019

Russo Adrian M, Lawther Adam J, Prior Benjamin M, Isbel Luke, Somers W Gregory, Lesku John A, Richdale Amanda L, Dissanayake Cheryl, Kent Stephen, Lowry Christopher A, Hale Matthew W

Abstract excerpt

Autism spectrum disorder (ASD) is a heterogeneous and highly heritable condition with multiple aetiologies. Although the biological mechanisms underlying ASD are not fully understood, evidence suggests that dysregulation of serotonergic systems play an important role in ASD psychopathology. Preclinical models using mice with altered serotonergic neurotransmission may provide insight into the role of serotonin in...

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Identifiers

PMID: 29935278
DOI: 10.1016/j.bbr.2018.06.019

Genes

TPH2

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