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Article

PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.

Aging - 8 Sept 2016

Choudhary Mayur, Ding Jin-Dong, Qi Xiaoping, Boulton Michael E, Yao Pei-Li, Peters Jeffrey M, Malek Goldis

Abstract excerpt

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a nuclear receptor that regulates differentiation, inflammation, lipid metabolism, extracellular matrix remodeling, and angiogenesis in multiple tissues. These pathways are also central to the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss globally. With the goal of identifying signaling pathways that may be...

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PMID: 27622388
DOI: 10.18632/aging.101031
PMCID: PMC5076447

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RPE

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