DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features

Abstract excerpt

The decreased antioxidant capacity in the retinal pigment epithelium (RPE) is the hallmark of retinal degenerative diseases including age-related macular degeneration (AMD). Nevertheless, the exact regulatory mechanisms underlying the pathogenesis of retinal degenerations remain largely unknown. Here we show in mice that deficiencies in Dapl1, a susceptibility gene for human AMD, impair the antioxidant capacity...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Retinal Development and Disorders
• Share to Retinal Diseases and Treatments
• Share to Retinoids in leukemia and cellular processes