Article

DAPL1 deficiency impairs autophagy in retinal pigment epithelium to drive age-dependent retinal pathologies

2025-06-11

Abstract excerpt

Age-related retinopathy, primarily comprising age-related macular degeneration (AMD), is a major cause of irreversible blindness in the elderly population worldwide. Although its precise mechanisms remain incompletely understood, autophagy deficiency in retinal pigment epithelium (RPE) cells has been associated with AMD in patients; however, the regulatory pathways involved are not fully elucidated. In this study,...

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Literature Corpus work: 2bc6d16b-9c21-58c5-8fec-dae715a226b2
DOI: 10.1101/2025.06.09.658638

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