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Article

Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevity

12 Mar 2014

Abstract excerpt

Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians (n = 184), measured at study enrollment, predict the duration of their incremental survival. In the Kaplan-Meier...

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PMID: 24618355
DOI: 10.1111/acel.12213

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