Article
A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity.
Nature - 1 Jan 2000
Nagaraja V, Shepherd J C, Bickle T A
Abstract excerpt
Early attempts to generate new restriction specificities by recombination between allelic restriction-modification systems have been unsuccessful. Bullas et al. succeeded in isolating a new specificity, SQ, in Salmonella that they interpreted as being the result of a recombination event between the parental strains, Salmonella typhimurium and S. postdam, which encode the SB and SP restriction systems,...
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