Article
Comparative genome hybridization array analysis for sporadic Parkinson's disease.
The International journal of neuroscience - 1 Sept 2008
Kim Joong-Seok, Yoo Ji-Yeon, Lee Kwang-Soo, Kim Hye Sung, Choi Jin Soo, Rha Hyoung Kyun, Yim Sung-Vin, Lee Kweon-Haeng
Abstract excerpt
Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31,...
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