Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From Genotype to Phenotype: A Primer on the Functional Follow-up of Genome-Wide Association Studies in Cardiovascular Disease.

Circulation. Genomic and precision medicine - 1 Feb 2018

Lin Jennie, Musunuru Kiran

Abstract excerpt

Genome-wide association studies (GWASs) have implicated many human genomic loci in the development of complex traits. The loci identified by these studies are potentially involved in novel pathways that contribute to disease pathophysiology. However, eventual therapeutic targeting of these pathways relies on bridging the gap between genetic association and function, a task that first requires validation of causal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29915816
PMCID: PMC6003539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From Genotype to Phenotype: A Primer on the Functional Follow-up of Genome-Wide Association Studies in Cardiovascular Disease.PMID 29915816Read ↗

The genetics of cardiovascular disease.Semantic proximity Read ↗

Genome-wide association studies of cardiovascular disease.Semantic proximity Read ↗

Understanding cardiovascular disease through the lens of genome-wide association studies.Semantic proximity Read ↗

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participantsSemantic proximity Read ↗

The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease.Semantic proximity Read ↗

Functionality-Informed Fine-Mapping Dissects Common Variant Contributions to Coronary Artery Disease and Identifies Causal Variants and PathwaysSemantic proximity Read ↗

From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.Semantic proximity Read ↗

Genetics 100 for cardiologists: basics of genome-wide association studies.Semantic proximity Read ↗

Cardiovascular diseases and genome-wide association studies.Semantic proximity Read ↗

Genome-wide association studies and contribution to cardiovascular physiology.Semantic proximity Read ↗

Exploring the genetic basis of coronary artery disease using functional genomics.Semantic proximity Read ↗

Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes: JACC Focus Seminar 1/5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.