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Article

Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease.

Neuroscience letters - 16 May 2012

Fang Yu, Zhang Lu, Zeng Zhaoshu, Lian Yajun, Jia Yanjie, Zhu Hongcan, Xu Yuming

Abstract excerpt

Depression is one of the most frequent neuropsychiatric symptoms in Alzheimer's disease (AD). As the main regulator of the tissue plasminogen activator/brain-derived neurotrophic factor axis, plasminogen activator inhibitor-1 (PAI-1) is involved in the pathogenesis of both AD and depression. This suggests a potential role of the PAI-1 gene SERPINE1 in the development of AD-related depression and its response to...

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Source

Identifiers

PMID: 22503724
DOI: 10.1016/j.neulet.2012.03.090

Genes

SERPINE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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