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DNA methylation dynamics at imprinted genes during bovine pre-implantation embryo development

9 Mar 2015

Abstract excerpt

BACKGROUND: In mammals, maternal differentially methylated regions (DMRs) acquire DNA methylation during the postnatal growth stage of oogenesis, with paternal DMRs acquiring DNA methylation in the perinatal prospermatagonia. Following fusion of the male and female gametes, it is widely accepted that murine DNA methylation marks at the DMRs of imprinted genes are stable through embryogenesis and early...

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PMID: 25881176
DOI: 10.1186/s12861-015-0060-2

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