Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing.

Molecular cancer research : MCR - 6 Jul 2022

Pham Minh-Tam, Gupta Anuj, Gupta Harshath, Vaghasia Ajay, Skaist Alyza, Garrison McKinzie A, Coulter Jonathan B, Haffner Michael C, Zheng S Lilly, Xu Jianfeng, DeStefano Shields Christina, Isaacs William B, Wheelan Sarah J, Nelson William G, Yegnasubramanian Srinivasan

Abstract excerpt

A limited number of cell lines have fueled the majority of preclinical prostate cancer research, but their genomes remain incompletely characterized. Here, we utilized whole-genome linked-read sequencing for comprehensive characterization of phased mutations and rearrangements in the most commonly used cell lines in prostate cancer research including PC3, LNCaP, DU145, CWR22Rv1, VCaP, LAPC4, MDA-PCa-2b, RWPE-1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Mutation

Share to Prostatic Neoplasms

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 35452513
DOI: 10.1158/1541-7786.MCR-21-0683
PMCID: PMC9262859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing.PMID 35452513Read ↗

Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome SequencingSemantic proximity Read ↗

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.Semantic proximity Read ↗

Patterns of Structural Variation Define Prostate Cancer Across Disease StatesSemantic proximity Read ↗

Patterns of structural variation define prostate cancer across disease statesSemantic proximity Read ↗

Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR.Semantic proximity Read ↗

Genomic Analyses of the Metastasis-derived LNCaP, VCaP, and PC3-AR Prostate Cancer Cell LinesSemantic proximity Read ↗

Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease ProgressionSemantic proximity Read ↗

Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines.Semantic proximity Read ↗

The genomic complexity of primary human prostate cancerSemantic proximity Read ↗

The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing.Semantic proximity Read ↗

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.Semantic proximity Read ↗

The genomic landscape of metastatic castration-resistant prostate cancers using whole genome sequencing reveals multiple distinct genotypes with potential clinical impactSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.