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Article

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Makena Anne, Brem Jürgen, Pfeffer Inga, Geffen Rebecca E J, Wilkins Sarah E, Tarhonskaya Hanna, Flashman Emily, Phee Lynette M, Wareham David W, Schofield Christopher J

Abstract excerpt

OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. This study compares the biochemical properties of seven clinically reported NDM variants. METHODS: NDM variants were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25324420
DOI: 10.1093/jac/dku403
PMCID: PMC4291237

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