Article
ADAR1 affects HCV infection by modulating innate immune response.
Antiviral research - 1 Aug 2018
Pujantell Maria, Franco Sandra, Galván-Femenía Iván, Badia Roger, Castellví Marc, Garcia-Vidal Edurne, Clotet Bonaventura, de Cid Rafael, Tural Cristina, Martínez Miguel A, Riveira-Muñoz Eva, Esté José A, Ballana Ester
Abstract excerpt
The hepatitis C virus (HCV) is a globally prevalent infectious pathogen. As many as 80% of people infected with HCV do not control the virus and develop a chronic infection. Response to interferon (IFN) therapy is widely variable in chronic HCV infected patients, suggesting that HCV has evolved mechanisms to suppress and evade innate immunity responsible for its control and elimination. Adenosine deaminase acting...
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