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Article

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

3 Aug 2009

Abstract excerpt

Adenosine deaminases that act on dsRNA (ADARs) are enzymes that target double-stranded regions of RNA converting adenosines into inosines (A-to-I editing) thus contributing to genome complexity and fine regulation of gene expression. It has been described that a member of the ADAR family, ADAR1, can target viruses and affect their replication process. Here we report evidence showing that ADAR1 stimulates human...

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PMID: 19651874
DOI: 10.1093/nar/gkp604

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