Article
Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship.
Virchows Archiv : an international journal of pathology - 1 Jul 2016
Ardighieri Laura, Mori Luigi, Conzadori Sara, Bugatti Mattia, Falchetti Marcella, Donzelli Carla Maria, Ravaggi Antonella, Odicino Franco E, Facchetti Fabio
Abstract excerpt
Pelvic carcinosarcomas (PCSs) are rare aggressive biphasic tumors that localize in the ovary, fallopian tube, or peritoneum and present frequently as bilateral disease. We undertook a morphological, p53 immunohistochemical and TP53 gene mutational analysis study in a single institution cohort of 16 PCSs in order to investigate the nature of bilateral tumors and to shed light on their origin and pathogenesis. Of...
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