Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling

2 Jun 2015

Abstract excerpt

Embryonic stem cells (ESCs) possess pluripotency, which is the capacity of cells to differentiate into all lineages of the mature organism. Increasing evidence suggests that the pluripotent state of ESCs is regulated by a combination of extrinsic and intrinsic factors. The underlying mechanisms, however, are not completely understood. Here, we show that March5, an E3 ubiquitin ligase, is involved in maintaining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26033541
DOI: 10.1038/ncomms8112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signallingPMID 26033541Read ↗

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read ↗

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signallingSemantic proximity Read ↗

Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency.Semantic proximity Read ↗

USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5Semantic proximity Read ↗

The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?Semantic proximity Read ↗

Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state.Semantic proximity Read ↗

JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming processSemantic proximity Read ↗

PINK1‐mediated mitophagy maintains pluripotency through optineurinSemantic proximity Read ↗

Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.Semantic proximity Read ↗

Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution.Semantic proximity Read ↗

Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.Semantic proximity Read ↗

MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.