Article
Cancer-mutation network and the number and specificity of driver mutations.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2018
Iranzo Jaime, Martincorena Iñigo, Koonin Eugene V
Abstract excerpt
Cancer genomics has produced extensive information on cancer-associated genes, but the number and specificity of cancer-driver mutations remains a matter of debate. We constructed a bipartite network in which 7,665 tumors from 30 cancer types are connected via shared mutations in 198 previously identified cancer genes. We show that about 27% of the tumors can be assigned to statistically supported modules, most...
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