Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease.

Arthritis research & therapy - 12 Jun 2018

Nakano Hiroto, Kirino Yohei, Takeno Mitsuhiro, Higashitani Kana, Nagai Hideto, Yoshimi Ryusuke, Yamaguchi Yukie, Kato Ikuma, Aoki Ichiro, Nakajima Hideaki

Abstract excerpt

BACKGROUND: Low C-C chemokine receptor 1 (CCR1) and interleukin (IL)-10 expression is associated with risk of Behçet's disease (BD). The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). METHODS: M1 and M2 macrophages (Mφ) were differentiated with granulocyte-macrophage colony-stimulating factor or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to Behcet Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Cell Plasticity

Share to Chemokine CCL3

Share to Interleukin-10

Share to Macrophage Activation

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 29895319
DOI: 10.1186/s13075-018-1613-0
PMCID: PMC5998575

Genes

CCR1
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease.PMID 29895319Read ↗

The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 PolarizationSemantic proximity Read ↗

Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet's disease.Semantic proximity Read ↗

Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behçet’s diseaseSemantic proximity Read ↗

Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammationSemantic proximity Read ↗

Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.Semantic proximity Read ↗

An optimized protocol for human M2 macrophages using M-CSF and IL-4/IL-10/TGF-β yields a dominant immunosuppressive phenotype.Semantic proximity Read ↗

Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammationSemantic proximity Read ↗

Distinct transcriptional profile of blood mononuclear cells in Behçet’s disease: insights into the central role of neutrophil chemotaxisSemantic proximity Read ↗

Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.Semantic proximity Read ↗

The role of classical and alternative macrophages in the immunopathogenesis of herpes simplex virus-induced inflammation in a mouse model.Semantic proximity Read ↗

Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.Semantic proximity Read ↗

Infiltrative classical monocyte-derived and <i>SPP1</i> lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.