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Article

Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.

Scientific reports - 20 Feb 2014

Tatano Yutaka, Shimizu Toshiaki, Tomioka Haruaki

Abstract excerpt

Mycobacterial infection induces suppressor macrophages (MΦs), causing disease exacerbation. There are two major MΦ subsets (M1 and M2 MΦs) that are phenotypically and functionally different. Here, we examined which of the MΦ subsets the mycobacterial infection-induced suppressor MΦs (MIS-MΦs) belong to. MIS-MΦs down-regulated T cell production of Th1 and Th2 cytokines but markedly increased production of...

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Identifiers

PMID: 24553452
DOI: 10.1038/srep04146
PMCID: PMC3930092

Genes

CCR7
TNF

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