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<i>Staphylococcus aureus</i> targets the purine salvage pathway to kill phagocytes

11 Jun 2018

Abstract excerpt

Significance Immune evasion by the human pathogen Staphylococcus aureus includes the synthesis of cytotoxic deoxyadenosine (dAdo) from neutrophil extracellular traps to eliminate macrophages. The signaling pathway that triggers dAdo-mediated apoptosis in macrophages is not known. By using a genome-wide CRISPR-Cas9 knockout screen, we demonstrate that S. aureus -derived dAdo targets the purine salvage pathway to...

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PMID: 29891696
DOI: 10.1073/pnas.1805622115

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