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Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli

22 Aug 2024

Abstract excerpt

Dysbiosis of the human gut microbiota is linked to numerous diseases. Understanding the molecular mechanisms by which microbes interact and compete with one another is required for developing successful strategies to modulate the microbiome. The natural product Microcin M (MccM) consists of a 77-residue bioactive peptide conjugated to a siderophore and is a class II microcin involved in microbial competition with...

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PMID: 39172990
DOI: 10.1021/acschembio.4c00226

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