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Article

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.

Nature chemical biology - 1 Jun 2018

Santiago Marina, Lee Wonsik, Fayad Antoine Abou, Coe Kathryn A, Rajagopal Mithila, Do Truc, Hennessen Fabienne, Srisuknimit Veerasak, Müller Rolf, Meredith Timothy C, Walker Suzanne

Abstract excerpt

Identifying targets of antibacterial compounds remains a challenging step in the development of antibiotics. We have developed a two-pronged functional genomics approach to predict mechanism of action that uses mutant fitness data from antibiotic-treated transposon libraries containing both upregulation and inactivation mutants. We treated a Staphylococcus aureus transposon library containing 690,000 unique...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29662210
DOI: 10.1038/s41589-018-0041-4
PMCID: PMC5964011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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