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Article

Mutational analysis of peptidoglycan amidase MepA.

Biochemistry - 9 Jan 2007

Firczuk Małgorzata, Bochtler Matthias

Abstract excerpt

Murein endopeptidase A (MepA) from Escherichia coli is a periplasmic peptidoglycan amidase that cleaves d,d amide bonds between d-alanine and meso-2,6-diaminopimelic acid in E. coli peptidoglycan. MepA and its homologues in other proteobacteria share overall structural similarity with d-Ala-d-Ala metallopeptidases and local similarity around the active site with lysostaphin-type enzymes, which has prompted the...

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PMID: 17198381
DOI: 10.1021/bi0613776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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