Article
The potential of coumatetralyl enhanced by cholecalciferol in the control of anticoagulant-resistant Norway rats (Rattus norvegicus).
Pest management science - 1 Feb 2017
Endepols Stefan, Klemann Nicole, Richter Dania, Matuschka Franz-Rainer
Abstract excerpt
BACKGROUND: We evaluated the potential of cholecalciferol as an enhancer of the first-generation anticoagulant coumatetralyl in the Westphalia anticoagulant-resistant strain of the Norway rat (Rattus norvegicus Berkenhout), characterised by the Tyr139Cys polymorphism on the VKOR enzyme. Because today only the most potent, but also most persistent anticoagulant rodenticides of the second generation remain...
Topics
- 4-Hydroxycoumarins
- Animals
- Anticoagulants
- Cholecalciferol
- Drug Resistance
- Female
- Germany
- Male
- Polymorphism, Single Nucleotide
- Rats
- Rodent Control
- Rodenticides
- Vitamin K Epoxide Reductases