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Article

DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster.

Pesticide biochemistry and physiology - 1 Jun 2018

Chen Xueting, Wang Yuanyuan, Wu Wenjun, Dong Ke, Hu Zhaonong

Abstract excerpt

Pyrethroid insecticides modify the gating of voltage-gated sodium channels, thus disrupting the function of the nervous system. In Drosophila melanogaster, para encodes a functional sodium channel. Drosophila Sodium Channel 1 (DSC1), although considered as a putative sodium channel gene for decades due to its high sequence similarity with sodium channels, encodes a voltage-gated cation channel with high...

Topics

Animals
Biological Assay
Calcium Channels
Drosophila Proteins
Drosophila melanogaster
Insecticide Resistance
Insecticides
Larva
Mutation
Neuromuscular Junction
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyrethrins

Voltage-Gated Sodium Channels

Source

Identifiers

PMID: 29891372
DOI: 10.1016/j.pestbp.2018.04.014

Genes

DSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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