Article
Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway.
Biochemical and biophysical research communications - 18 Sept 2015
Zhu Guohua, Wang Yun, Mijiti Maimaitili, Wang Zengliang, Wu Peng-Fei, Jiafu Dangmuren
Abstract excerpt
The Hippo signaling pathway plays a crucial role in suppressing tumorigenesis. Physiologically, The Hippo signaling largely restricts its two downstream effectors, homologous oncoproteins Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), to a low level of activity by the MST1-SAV1 complex-induced kinase cascade. However, how the negative regulation induced by MST1-SAV1...
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