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Article

DNA-binding induced conformational change of c-Myb R2R3 analyzed using diffracted X-ray tracking.

Biochemical and biophysical research communications - 3 Sept 2018

Hosoe Yuhi, Inaba Satomi, Sekiguchi Hiroshi, Sasaki Yuji C, Oda Masayuki

Abstract excerpt

Previous structural analyses have shown that R2R3, the minimum unit of the DNA-binding domain of the transcriptional factor c-Myb, is largely flexible in solution, and changes to a more rigid structure upon DNA binding. In this study, we evaluated the structural dynamics using the diffracted X-ray tracking method, in correlation with DNA-binding abilities under different salt conditions, and compared them with...

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Identifiers

PMID: 29885838
DOI: 10.1016/j.bbrc.2018.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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