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Article

Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation.

Nucleic acids research - 1 Jan 2012

Wei Shu-Yi, Lou Yuan-Chao, Tsai Jia-Yin, Ho Meng-Ru, Chou Chun-Chi, Rajasekaran M, Hsu Hong-Ming, Tai Jung-Hsiang, Hsiao Chwan-Deng, Chen Chinpan

Abstract excerpt

Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a hydrogenosomal malic enzyme that may play a role in the cytoadherence of the parasite. Here, we identified tvMyb3(53-180) as the essential fragment for DNA recognition and report the crystal structure of tvMyb3(53-180) bound to MRE-1 DNA. The N-terminal fragment adopts the...

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Identifiers

PMID: 21908401
DOI: 10.1093/nar/gkr707
PMCID: PMC3245928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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