Article

Homologous BHLH transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanism

2022-01-07

Abstract excerpt

Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcription factors (TFs) to DNA. Despite the importance, the mechanistic details on how torsional stress impacts the TFs-DNA complexation remain scarce. Herein we address th...

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Literature Corpus work: cfb73ce3-0658-5330-b35f-7d6e1df99337
DOI: 10.1101/2022.01.07.475332

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