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Article

Distinct Activities of Glycolytic Enzymes Identify Chronic Lymphocytic Leukemia Patients with a more Aggressive Course and Resistance to Chemo-Immunotherapy.

EBioMedicine - 1 Jun 2018

Gdynia Georg, Robak Tadeusz, Kopitz Jürgen, Heller Anette, Grekova Svetlana, Duglova Katarina, Laukemper Gloria, Heinzel-Gutenbrunner Monika, Gutenbrunner Cornelius, Roth Wilfried, Ho Anthony D, Schirmacher Peter, Schmitt Michael, Dreger Peter, Sellner Leopold

Abstract excerpt

A higher capacity to grow under hypoxic conditions can lead to a more aggressive behavior of tumor cells. Determining tumor activity under hypoxia may identify chronic lymphocytic leukemia (CLL) with aggressive clinical course and predict response to chemo-immunotherapy (CIT). A metabolic score was generated by determining pyruvate kinase and lactate dehydrogenase, key enzymes of glycolysis, ex vivo in primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29884457
DOI: 10.1016/j.ebiom.2018.05.030
PMCID: PMC6021262

Genes

CIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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