Article
Collagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Gene - 5 Oct 2018
Gantala Srilatha Reddy, Kondapalli Mrudula Spurthi, Kummari Ramanjaneyulu, Padala Chiranjeevi, Tupurani Mohini Aiyengar, Kupsal Keerthi, Galimudi Rajesh Kumar, Gundapaneni Kishore Kumar, Puranam Kaushik, Shyamala Nivas, Guditi Swarnalatha, Rapur Ram, Hanumanth Surekha Rani
Abstract excerpt
Type 2 Diabetic Nephropathy (DN) is a common multifactorial disorder. Degradation of glomerular basement membrane (GBM) by matrix metalloproteases (MMPs) is a key event in the progression of renal disease. A functional polymorphism at position -1607 1G/2G, -1306 C/T and -1171 5A/6A has been shown to alter the transcriptional activity of MMP-1, MMP-2, and MMP-3 respectively, and also associated with several...
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