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Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R

27 Aug 2024

Abstract excerpt

There has been an alarming trend toward earlier puberty in girls, suggesting the influence of an environmental factor(s). As the reactivation of the reproductive axis during puberty is thought to be mediated by the hypothalamic neuropeptides kisspeptin and gonadotropin-releasing hormone (GnRH), we asked whether an environmental compound might activate the kisspeptin (KISS1R) or GnRH receptor (GnRHR). We used...

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PMID: 39254333
DOI: 10.1210/endocr/bqae103

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