Article
HuR regulates telomerase activity through TERC methylation.
Nature communications - 7 Jun 2018
Tang Hao, Wang Hu, Cheng Xiaolei, Fan Xiuqin, Yang Fan, Zhang Mengmeng, Chen Yanlian, Tian Yuyang, Liu Cihang, Shao Dongxing, Jiang Bin, Dou Yali, Cong Yusheng, Xing Junyue, Zhang Xiaotian, Yi Xia, Songyang Zhou, Ma Wenbin, Zhao Yong, Wang Xian, Ma Jinbiao, Gorospe Myriam, Ju Zhenyu, Wang Wengong
Abstract excerpt
Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates with TERC and promotes the assembly of the TERC/TERT complex by facilitating TERC C106 methylation. Dyskeratosis congenita (DC)-related TERC U100A mutation impair the association of HuR...
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