Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation.

Journal of virology - 1 Jan 2012

Horst Daniëlle, Burrows Scott R, Gatherer Derek, van Wilgenburg Bonnie, Bell Melissa J, Boer Ingrid G J, Ressing Maaike E, Wiertz Emmanuel J H J

Abstract excerpt

The Epstein-Barr virus (EBV)-encoded immune evasion protein BNLF2a inhibits the transporter associated with antigen processing (TAP), thereby downregulating HLA class I expression at the cell surface. As a consequence, recognition of EBV-infected cells by cytotoxic T cells is impaired. Here, we show that sequence polymorphism of the BNLF2a protein is observed with natural EBV isolates, with evidence for positive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epstein-Barr Virus Infections

Share to Herpesvirus 4, Human

Share to Histocompatibility Antigens Class I

Share to Immune Evasion

Share to T-Lymphocytes, Cytotoxic

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22013037
DOI: 10.1128/JVI.05151-11
PMCID: PMC3255881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation.PMID 22013037Read ↗

Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen PresentationSemantic proximity Read ↗

Sequence analysis of EBV immune evasion gene BNLF2a in EBV associated tumors and healthy individuals from nasopharyngeal carcinoma endemic and non-endemic regions of China.Semantic proximity Read ↗

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle.Semantic proximity Read ↗

The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.Semantic proximity Read ↗

Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a , in EBV-Positive Gastric CarcinomasSemantic proximity Read ↗

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primatesSemantic proximity Read ↗

Immunoinformatic Analysis Reveals Antigenic Heterogeneity of Epstein-Barr Virus Is Immune-DrivenSemantic proximity Read ↗

EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail.Semantic proximity Read ↗

The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-IISemantic proximity Read ↗

Epstein-Barr Virus Evades CD4+ T Cell Responses in Lytic Cycle through BZLF1-mediated Downregulation of CD74 and the Cooperation of vBcl-2Semantic proximity Read ↗

Identification of a TAP-Independent, Immunoproteasome-Dependent CD8<sup>+</sup>T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2Semantic proximity Read ↗

Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.