Article

A theoretical model of mitochondrial ATP synthase deficiencies. The role of mitochondrial carriers

2021-07-14

Abstract excerpt

The m.8993T > G mutation of the mitochondrial MT-ATP6 gene is associated with NARP syndrome (Neuropathy, Ataxia and Retinitis Pigmentosa). The equivalent point mutation introduced in yeast Saccharomyces cerevisiae mitochondrial DNA considerably reduced the activity of ATP synthase and of cytochrome-c-oxidase preventing yeast growth on oxidative substrates. The over-expression of the mitochondrial oxodicarboxyla...

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Literature Corpus work: 26d7c5c1-28f9-5e60-a8d5-e5f7cb13294a
DOI: 10.1101/2021.07.13.452228

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