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Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects

7 May 2021

Abstract excerpt

Abstract Glutamine synthetase (GS) in the liver is expressed in a small perivenous, highly specialized hepatocyte population and is essential for the maintenance of low, non-toxic ammonia levels in the organism. However, GS activity can be impaired by tyrosine nitration of the enzyme in response to oxidative/nitrosative stress in a pH-sensitive way. The underlying molecular mechanism as investigated by combined...

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PMID: 33962502
DOI: 10.1515/hsz-2021-0166

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