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Article

α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells.

Metabolic engineering - 1 Jul 2020

Lesner Nicholas P, Gokhale Amrita S, Kota Kalyani, DeBerardinis Ralph J, Mishra Prashant

Abstract excerpt

Pathogenic mutations in the mitochondrial genome (mtDNA) impair organellar ATP production, requiring mutant cells to activate metabolic adaptations for survival. Understanding how metabolism adapts to clinically relevant mtDNA mutations may provide insight into cellular strategies for metabolic flexibility. In this study, we use 13C isotope tracing and metabolic flux analysis to investigate central carbon and...

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Identifiers

PMID: 32330654
DOI: 10.1016/j.ymben.2020.03.010
PMCID: PMC7310915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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