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Article

Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease.

Circulation. Genomic and precision medicine - 1 Jan 2018

Thériault Sébastien, Lali Ricky, Chong Michael, Velianou James L, Natarajan Madhu K, Paré Guillaume

Abstract excerpt

BACKGROUND: Despite evidence of high heritability, monogenic disorders are identified in a minor fraction of individuals with early-onset coronary artery disease (EOCAD). We hypothesized that some individuals with EOCAD carry a high number of common genetic risk variants, with a combined effect similar to Mendelian forms of coronary artery disease, such as familial hypercholesterolemia. METHODS AND RESULTS: To...

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PMID: 29874178
DOI: 10.1161/CIRCGEN.117.001849

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