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Article

Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model.

Clinical biochemistry - 1 Feb 2006

Nassar Bassam A, Rockwood Kenneth, Kirkland Susan A, Ransom Thomas P, Darvesh Sultan, MacPherson Kathleen, Johnstone David E, O'Neill Blair J, Bata Iqbal R, Andreou Pantelis, Jeffery Julie S, Cox Jafna L, Title Lawrence M

Abstract excerpt

OBJECTIVES: Coronary artery disease (CAD) is often polygenic due to multiple mutations that contribute small effects to susceptibility. Since most prior studies only evaluated the contribution of single candidate genes, we therefore looked at a combination of genes in predicting early-onset CAD [apolipoprotein E (APOE) epsilon4, butyrylcholinesterase (BChE) K, peroxisome proliferator-activated receptor gamma2...

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Source

Identifiers

PMID: 16298355
DOI: 10.1016/j.clinbiochem.2005.10.002

Genes

CAD
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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