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Article

Rare coding TTN variants are associated with electrocardiographic QT interval in the general population.

Scientific reports - 20 Jun 2016

Kapoor Ashish, Bakshy Kiranmayee, Xu Linda, Nandakumar Priyanka, Lee Dongwon, Boerwinkle Eric, Grove Megan L, Arking Dan E, Chakravarti Aravinda

Abstract excerpt

We have shown previously that noncoding variants mapping around a specific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for associations with QT interval than observed for genome-wide comparisons. At a false discovery rate (FDR) of 5%, we had identified 28 such ID protein-encoding genes. Here, we assessed whether coding variants at these 28 genes affect QT interval in...

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Identifiers

PMID: 27321809
DOI: 10.1038/srep28356
PMCID: PMC4913250

Genes

TTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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