Article
Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors.
JAMA oncology - 1 Nov 2018
Ptashkin Ryan N, Mandelker Diana L, Coombs Catherine C, Bolton Kelly, Yelskaya Zarina, Hyman David M, Solit David B, Baselga José, Arcila Maria E, Ladanyi Marc, Zhang Liying, Levine Ross L, Berger Michael F, Zehir Ahmet
Abstract excerpt
Importance: Although clonal hematopoiesis (CH) is well described in aging healthy populations, few studies have addressed the practical clinical implications of these alterations in solid-tumor sequencing. Objective: To identify and quantify CH-related mutations in patients with solid tumors using matched tumor-blood sequencing, and to establish the proportion that would be misattributed to the tumor based on...
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