Fragment Size Analysis May Distinguish Clonal Hematopoiesis from Tumor-Derived Mutations in Cell-Free DNA

Abstract excerpt

To the Editor: Noninvasive detection of somatic, solid tumor-derived mutations in the blood is an important clinical and investigative tool. However, analysis of cell-free DNA (cfDNA) for somatic mutations can be confounded by the presence of mutations that are not of tumor origin. These include germline alterations, mutations from clonal events in nonneoplastic tissue, and artifacts from the sequencing process...

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