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Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.

JCO precision oncology - 1 Aug 2023

Franch-Expósito Sebastià, Mehine Miika, Ptashkin Ryan N, Bolton Kelly L, Bandlamudi Chaitanya, Srinivasan Preethi, Zhang Linda, Goodell Margaret A, Gedvilaite Erika, Menghrajani Kamal, Sánchez-Vela Pablo, Mandelker Diana, Comen Elizabeth, Norton Larry, Benayed Ryma, Gao Teng, Papaemmanuil Elli, Taylor Barry, Levine Ross, Offit Kenneth, Stadler Zsofia, Berger Michael F, Zehir Ahmet

Abstract excerpt

PURPOSE: Clonal hematopoiesis (CH), the expansion of clones in the hematopoietic system, has been linked to different internal and external features such as aging, genetic ancestry, smoking, and oncologic treatment. However, the interplay between mutations in known cancer predisposition genes and CH has not been thoroughly examined in patients with solid tumors. METHODS: We used prospective tumor-blood paired...

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Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics
Clonal Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

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PMID: 37561983
DOI: 10.1200/PO.23.00070
PMCID: PMC10581611

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