Article
NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.
Scientific reports - 23 May 2018
Nishida Nao, Aiba Yoshihiro, Hitomi Yuki, Kawashima Minae, Kojima Kaname, Kawai Yosuke, Ueno Kazuko, Nakamura Hitomi, Yamashiki Noriyo, Tanaka Tomohiro, Tamura Sumito, Mori Akira, Yagi Shintaro, Soejima Yuji, Yoshizumi Tomoharu, Takatsuki Mitsuhisa, Tanaka Atsushi, Harada Kenichi, Shimoda Shinji, Komori Atsumasa, Eguchi Susumu, Maehara Yoshihiko, Uemoto Shinji, Kokudo Norihiro, Nagasaki Masao, Tokunaga Katsushi, Nakamura Minoru
Abstract excerpt
Approximately 10-20% of patients with primary biliary cholangitis (PBC) progress to jaundice stage regardless of treatment with ursodeoxycholic acid and bezafibrate. In this study, we performed a GWAS and a replication study to identify genetic variants associated with jaundice-stage progression in PBC using a total of 1,375 patients (1,202 early-stage and 173 jaundice-stage) in a Japanese population. SNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.