Article
Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of De Novo Phosphatidylethanolamine Synthesis.
Infection and immunity - 1 Aug 2018
Davis Sarah E, Tams Robert N, Solis Norma V, Wagner Andrew S, Chen Tian, Jackson Joseph W, Hasim Sahar, Montedonico Anthony E, Dinsmore Justin, Sparer Timothy E, Filler Scott G, Reynolds Todd B
Abstract excerpt
Candida albicans mutants for phosphatidylserine (PS) synthase (cho1ΔΔ) and PS decarboxylase (psd1ΔΔ psd2ΔΔ) are compromised for virulence in mouse models of systemic infection and oropharyngeal candidiasis (OPC). Both of these enzymes are necessary to synthesize phosphatidylethanolamine (PE) by the de novo pathway, but these mutants are still capable of growth in culture media, as they can import ethanolamine...
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