Article
Loss of phosphatidylserine synthesis results in aberrant solute sequestration and vacuolar morphology in Saccharomyces cerevisiae.
FEBS letters - 4 Jul 1994
Hamamatsu S, Shibuya I, Takagi M, Ohta A
Abstract excerpt
Null cho1 mutants of Saccharomyces cerevisiae are incapable of phosphatidyl-serine synthesis. They were more susceptible than wild-type strains to 100 mM CaCl2, 3 mM ZnCl2 or 1 mM MnCl2, but not to MgCl2 nor KCl. They were also susceptible to high concentrations of basic amino acids, L-lysine and L-arginine, and to an L-lysine analog, S-2-aminoethyl-L-cysteine. Their vacuolar pools of amino acids, especially...
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