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Article

Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease.

Epigenetics - 3 Mar 2016

Cortese Rene, Lu Lei, Yu Yueyue, Ruden Douglas, Claud Erika C

Abstract excerpt

Preterm birth is the leading cause of infant morbidity and mortality. Necrotizing enterocolitis (NEC) is an inflammatory bowel disease affecting primarily premature infants, which can be lethal. Microbial intestinal colonization may alter epigenetic signatures of the immature gut establishing inflammatory and barrier properties predisposing to the development of NEC. We hypothesize that a crosstalk exists between...

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Identifiers

PMID: 26909656
DOI: 10.1080/15592294.2016.1155011
PMCID: PMC4854540

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