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Article

Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma

1 Jan 2013

Abstract excerpt

Development of asthma in childhood is linked to viral infections of the lower respiratory tract in early life, with subsequent chronic exposure to allergens. Progression to persistent asthma is associated with a Th2-biased immunological response and structural remodelling of the airways. The underlying mechanisms are unclear, but could involve epigenetic changes. To investigate this, we employed a recently...

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PMID: 23611895
DOI: 10.1242/dmm.011247

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