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Article

DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling.

PloS one - 1 Jan 2018

Liao Wen-Chieh, Liao Chih-Kai, Tsai You-Huan, Tseng To-Jung, Chuang Li-Ching, Lan Chyn-Tair, Chang Hung-Ming, Liu Chiung-Hui

Abstract excerpt

Remodeling of the extracellular matrix (ECM) in the tumor microenvironment promotes glioma progression. Chondroitin sulfate (CS) proteoglycans appear in the ECM and on the cell surface, and can be catalyzed by dermatan sulfate epimerase to form chondroitin sulfate/dermatan sulfate (CS/DS) hybrid chains. Dermatan sulfate epimerase 1 (DSE) is overexpressed in many types of cancer, and CS/DS chains mediate several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29864158
DOI: 10.1371/journal.pone.0198364
PMCID: PMC5986151

Genes

DSE
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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