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Article

Comorbid epilepsy in autism spectrum disorder: Implications of postnatal inflammation for brain excitability.

Epilepsia - 1 Jul 2018

Lewis Megan Leigh, Kesler Mitchell, Candy Sydney A, Rho Jong M, Pittman Quentin J

Abstract excerpt

OBJECTIVE: In different cohorts, 5%-30% of individuals with autism spectrum disorder (ASD) also have epilepsy. The high co-occurrence of these disorders suggests that a common mechanistic link may exist. The underlying pathophysiology of this comorbidity remains unknown. To investigate the mechanism(s) involved in the pathogenesis of ASD and epilepsy, we developed and validated a novel mouse model that...

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Identifiers

PMID: 29858515
DOI: 10.1111/epi.14440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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